Course readings will be posted here at least a week in advance of class.

Readings are to be done before class. There will be a small quiz at the start of each lecture that relates to material to be covered that day.

 January 7th, 2008 | Course Introduction, Immunology Lecture

1. Drugs for the Masses (Ellen Schwartz)
    (Handed out in class).

2. Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, TB and Malaria (Hotez et al.)

January 14th, 2008 | Gastrointestinal Bacterial Infections

1. Cholera overview – brief (World Health Organization)

2. Vibrio Cholerae and Asiatic Cholera (Todar’s online textbook)

3. Cholera review (ecology, treatment, vaccines) (Sanchez and Taylor)
    – Omit section titled “Microbiology of V Cholerae” 

4.  Cholera Vaccines – World Health Organization Position Paper (WHO)
    – Read for major concepts and be ready to discuss in class.

5. Vibrio cholerae and cholera – out of the water and into the host (Reidl and Close)
    – An extra paper for discussion leaders. Not directly tested.

E. Coli
1. The epidemiology, pathogenicity and microbiology of foodborne Escherichia coli 0157:H7 (Josephs et al.)

2. Pathogenic E coli (Todar`s online textbook)

3. Domestic hygiene and diarrhoea – pinpointing the problem (Curtis et al.)
    – Read for major concepts and be ready to discuss in class.

January 21st, 2008 | Malaria, African & American Trypanosomiasis

1. Malaria – An Overview (Tuteja)

2. Malaria misdiagnosis – effects on the poor and vulnerable (Amexo et al.)

3. The long road to malaria eradication (Majori)

4. The pathogenic basis of malaria (Miller et al.)
    – An extra paper for discussion leaders. Not directly tested.

African Trypanosomiasis (sleeping sickness) and American Trypanosomiasis (Chagas’ disease)
1. Trypanosomiasis – African and American (Krishna and Stich)

2. Chagas’ disease (Umezawa et al.)

3. Control of sleeping sickness – Time to integrate approaches (Kioy, Mattock)
    – For discussion

January 28th, 2008 | Tuberculosis, Schistosomiasis

1. The resumption of consumption – A review on tuberculosis (Ducati et al.)
    – Only skim sections titled “Tuberculosis resumption”, “M. tuberculosis genome” and “Immune system of TB”. Not testable.

2. Challenges of tuberculosis control (Murray, an editorial)
    – For discussion

1. Schistosomiasis: Overview of the history, biology, clinicopathology, and laboratory diagnosis (Coon)

2. Schistosomiasis (Conlon)

3. Why don’t we have a schistosomiasis vaccine? (Wilson and Coulson, 1998)
    – For discussion

February 4th, 2008 | Yellow Fever, Dengue Fever, Leprosy & Plague

Yellow Fever
1. Yellow fever – An update (Monath, 2001)

2. Yellow fever (Monath, 2005)

Dengue Fever
1. Dengue (Jacobs, 2005)

2. Epidemic dengue and dengue hemorrhagic fever as a public health, social and economic problem in the 21st century (Gubler, 2002)
    – For discussion

3. Dengue and dengue hemorrhagic fever (Gubler, 1998)
    – An extra paper for discussion leaders. Not directly tested.

1. Leprosy (Lockwood, 2005)

1. Plague (Sorabjee, 2005)

2. Tropical and exotic infections (Beeching et al., 1998)
    – Read pages 2-5, section titled “Plague”.

3. Plague as a biological weapon – Medical and public health management (Inglesby et al., 2000)
    – For discussion

March 3rd, 2008 | New approaches to research and implementation of interventions

1.  Fighting Tropical Diseases (Sachs & Hotez, 2006. In: Science)

2. Implementation Science (Madon et al., 2007. In: Science)

3. Diagnostics for the Developing World (Mabey et al., 2004. In: Nature Reviews)

4. “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa’s Neglected Tropical Diseases Could Benefit the Poor (Molyneux et al., 2005. In: PLoS Medicine

March 10th, 2008 | Issues in Malaria eradication, the side effects of doing good

1. Conquering the Intolderable Burden of Malaria: What’s New, What’s Needed (Breman et al., 2004. In: American Journal of Tropical Medicine and Hygiene)

2. The Economic and Social Burden of Malaria (Sachs & Malaney., 2002. In: Nature)

3. The side effects of doing good (2008. In: The Economist)

March 17th, 2008 | Tackling HIV, Pharmaceuticals and the industry

1. The HIV/AIDS Epidemic in Africa: Implications for US Policy (Gow, 2002. In: Project Hope)

2. International Response to the HIV/AIDS Epidemic: Planning for Success (Piot & Seck, 2001. In: Bulletin of the World Health Organization)

3. Bottom Line for (Red) (Nixon, Feb 2008. In: The New York Times)

4. The Pharmaceutical Industry as a Medicines Provider (Henry & Lexchin, 2002. In: The Lancet)

5. Public-Private Partnership: From There to Here (Croft, 2005. In: Royal Society of Tropical Medicine and Hygiene)

6. From Pipleline to Patients (Pecoul, 2004. In: PlosMedicine)

7. Drugs for Neglected Diseases (Zumla, 2002. In: The Lancet Infectious Diseases)

March 31st, 2008 | Climate Change and Open Source Solutions

1. Effects of Environmental Change on Emerging Parasitic Diseases (Patz et al., 2000. In: International Journal for Parasitology)

2. Climate Change and Emerging Infectious Diseases (Epstein, 2001. In: Microbes and Infection)

3. Finding Cures for Tropical Diseases: Is Open Source the Answer? (Maurer et al., 2004. In: PlosMedicine)

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